Features of ectopic lymphoid-like structures in human uveitis

Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, and systemic lupus erythematosus. ELS are characterized by the formation of organized T/B cells aggregates, which can acquire follicular dendritic cells network supporting an ectopic germinal c...

Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models

Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the acetylcholine receptor (AChR) at the neuromuscular junction. MG symptoms are characterized by muscle weaknesses. The thymus of MG patients is very often abnormal and possesses all the characteristics of tertiary lymphoid organs such as neoangiogenesis processes, overexpression of inflammatory cytokines and ch...

The pathological features of ectopic lymphoid neogenesis in idiopathic dacryoadenitis

BACKGROUND Lymphoid neogenesis has been reported in various diseases but not in idiopathic dacryoadenitis. The aim of this paper is to discuss the pathological features of lymphoid neogenesis in idiopathic dacryoadenitis. METHODS 20 cases of idiopathic dacryoadenitis were collected retrospectively. Lymphoid neogenesis was graded by lymphocytic aggregates and germinal center-like structure for...

IL-27 shakes up the establishment of ectopic lymphoid structures

1754 INSIGHTS | The Journal of Experimental Medicine The establishment of complex behaviors, memory, and language has long fascinated humanity. It is, after all, what makes us human. Understanding this complexity presents one of the most significant challenges in biomedical research. Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders often characterized by repetitive a...

Avian lymphoid leukosis: Virus-like particles in kidney Cells